Streptomycin-Dependent Exhibition of Cytokine-Inducing Activity in Streptomycin-Dependent Mycobacterium tuberculosis Strain 18b

Streptomycin-dependent exhibition of cytokine-inducing activity in streptomycin-dependent Mycobacterium tuberculosis strain 18b.

Peritoneal exudate cells of mice were stimulated with a streptomycin-dependent Mycobacterium tuberculosis strain, 18b. Gamma interferon production by natural killer cells depending on interleukin-12 and interleukin-18 was induced only in the presence of a high dose of streptomycin. This study suggested the requirement of active bacterial metabolism for this host response.

Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis.

Mycobacterium tuberculosis 18b, a streptomycin (STR)-dependent mutant that enters a viable but nonreplicating state in the absence of STR, has been developed as a simple model for drug testing against dormant bacilli. Here, we further evaluated the STR-starved 18b (SS18b) model both in vitro and in vivo by comparing the behavior of 22 approved and experimental tuberculosis drugs. Using the resa...

Heterogeneous character of streptomycin-dependent mutants of a Mycobacterium.

It has recently been shown that streptomycin-dependent variants from certain species of microorganisms differ from the original parent type in colony morphology, growth rate, and pigment production, but in other species no visible differences are observed (Yegian and Budd, 1948; Yegian and Vanderlinde, 1950). Until the present report all of the streptomycin-dependent mutants studied have been f...

Streptomycin in Tuberculosis

Streptomycin Therapy in Tuberculosis

The following is a report on the effect of streptomycin in twenty-one suitable cases of tuberculosis treated in the Hardinge Hospital (Dharampore and Arcadia Dharampore) during the year 1948. Clinical material.?All patients in this series had pulmonary tuberculosis which, prior to streptomycin therapy, had not responded to bedrest or other accepted forms, of treatment. There was roentgenographi...